Issues of functional and topographic anatomy of the dental system after the complete loss of natural teeth highlighted in the manual presented by the team of authors of the department of orthopedic dentistry with implantology. Based on the analysis of the data in this discipline, the essence and sequence of clinical and laboratory stages of complete removable dentures fabrication are reviewed, taking into account individual features of the structure of the foundation area and use elaborations of the department's staff aimed at improving the fixation and stabilization of dentures. The manual is intended for students of dental faculties of higher education institutions, interns and English-speaking dentists.