The textbook is composed in accordance with curriculum in the specialty “General Practice — Family Medicine". The textbook presents the current approach to common problems in family physician practice, highlights the main symptoms and syndromes in cardiology, gastroenterology, pulmonology, nephrology, hematology, endocrinology as well as other syndromes that general practitioner-family physician most often manages in medical practical activity. Information on the causes, pathogenesis, clinical manifestations, diagnostic search algorithms in the presence of these syndromes, differential diagnosis of various diseases manifested by these symptoms and syndromes is provided in the textbook. Assessment and treatment algorithms, first aid managing and practical recommendations are proposed in detail. For students of higher education establishments — medical universities, institutes and academies, internship doctors in the specialty “General Practice — Family Medicine".