In the 28 years of its existence, the Essentials of Medical Pharmacology is appearing as the 7th edition. Commensurate with tremendous transformation of pharmacology and clinical medicine in this period, the book has undergone successive changes to reflect the current status of pharmacological knowledge and therapeutic practices. Selection of the subject content of this edition places due emphasis on the understanding gained in mechanism of action of drugs, as well as on evidence based medicine. It abundantly quotes current guidelines issued by WHO and other eminent professional bodies as well as by Indian National Health Programmes to authenticate therapeutic recommendations. Medical pharmacology is a unique synthesis of basic pharmacology with clinical pharmacology andpharmacotherapeutics. The subject is highly dynamic. Developments are occurring both in definingmolecular targets for drug action and finding targeted drugs, as well as in accruing credible evidenceregarding the impact of different treatment modalities on therapeutic outcomes. These efforts havebegun to crystallize into evidence based medicine and clear cut therapeutic guidelines. The presentedition endeavours to amalgamate the developments with the core content of the subject.