The manual is intended for the independent study of Physical Chemistry as a part of the general theoretical training of students at higher medical and pharmaceutical educational institutions. The manual consists of 5 sections and contains over 350 tasks with illustrations, charts, tables and task solving examples. Each section begins with a review that outlines the main theoretical issues and provides guidance for a self-learning approach. The manual, thus, provides the main problemsolving skills that are critical to understanding and applying the basic principles of Physical Chemistry. It is recommended by the Ministry of Education and Science of Ukraine as a textbook for English-speaking students of higher medical and pharmaceutical educational institutions of the III - IV accreditation levels.